Getting started
📅Your first week — what to expect
A realistic picture of the first seven days on a GLP-1 medication, including what's normal and what to watch for.
Starting your first week
The first week on a GLP-1 medication is often the most uncertain. Your body is adjusting to a new hormonal signal, and side effects — if they occur — are most likely to show up now. Understanding what is normal helps you stay on track.
What many people notice in week 1
Reduced appetite — You may find that you feel full sooner than usual, or that food simply seems less appealing. This can feel strange at first, especially if you are used to larger portions.
Mild nausea — This is the most common side effect and tends to be mild in the first week at the starting dose. It is often worse after eating too quickly or eating fatty, rich foods.
Fatigue — Some people feel tired in the first few days. Your body is adjusting.
No change in appetite — Some people feel nothing at all in week one. This is also normal. The appetite-reducing effect typically becomes more noticeable as the dose increases over subsequent weeks.
What to eat in week 1
Keep meals:
- Small — eat less than you think you need, even if you don't feel full yet
- Low in fat — fatty foods are harder to digest with slowed gastric emptying
- Bland if nauseous — plain rice, toast, crackers, and broth are good options
- Eaten slowly — take your time and stop at the first sign of fullness
Avoid:
- Large portions
- Greasy, fried, or very rich foods
- Eating right before bed
- Carbonated drinks (can worsen nausea and bloating)
Hydration matters from day one
Drink water consistently throughout the day — aim for at least 1.5–2 litres. Nausea is often worsened by dehydration, and reduced food intake can mean less water from food sources.
Injection day tips
- Inject on the same day each week (for weekly medications)
- Note any injection site reactions — mild redness or itching is common and normal
- Some people feel slightly worse the day of or after injection — plan lighter meals on that day
When to contact your prescriber
- Severe or persistent vomiting (more than 2–3 days)
- Inability to keep fluids down
- Severe abdominal pain (not just mild discomfort)
- Signs of an allergic reaction (rash, swelling, difficulty breathing)
Contact your prescriber if anything concerns you. This guide is general information only — not medical advice.
General lifestyle information only — not medical advice. Always follow your prescriber's instructions.