Mazdutide

Nutrition: Eat small, frequent meals (5–6 times per day rather than 3 large meals), Choose bland, low-fat foods such as plain rice, toast, boiled potato, or crackers, Try eating slowly and chewing thoroughly, Avoid eating right before your injection — wait at least 1–2 hours after dosing if possible

Hydration: Sip water or clear fluids steadily throughout the day, Cold or room-temperature fluids are often better tolerated than hot drinks, Try ginger tea or ginger-flavoured water if helpful

Avoid: Rich, fatty, or heavily spiced meals, Large meal portions, Lying down immediately after eating, Strong food odours if they trigger nausea

Nutrition: Reduce meal size further — small snacks every 2–3 hours may be easier to manage, Prioritise easy-to-digest foods: plain crackers, banana, boiled chicken, plain yoghurt, Avoid skipping meals entirely as an empty stomach can worsen nausea, Cold foods (e.g., chilled fruit, yoghurt) may be better tolerated than hot meals

Hydration: Aim to sip at least 1.5–2 L of fluid across the day in small amounts, Oral rehydration solutions can help if nausea is affecting your fluid intake, Avoid carbonated drinks if they increase discomfort

Avoid: Alcohol, High-fat or fried foods, Caffeine if it worsens symptoms, Large gaps between eating

⚠ If moderate nausea persists for more than 48 hours or is stopping you from eating or drinking adequately, contact your trial site.

Nutrition: Focus on keeping any food down — small sips of broth, plain crackers, or oral rehydration drinks, Do not force eating if vomiting is frequent, Your trial site may have anti-nausea medication options — ask promptly

Hydration: Hydration is the priority — aim for small, frequent sips even if food is not tolerated, Seek guidance from your trial site if you cannot keep fluids down for more than 12 hours

Avoid: Solid foods until vomiting resolves, Any foods with strong smells, Taking other oral medications without checking with your trial site first

⚠ Severe nausea (score 7–10), vomiting for more than 12 hours, or inability to keep any fluids down — contact your trial site urgently or seek medical attention.

Nutrition: Gradually increase dietary fibre: add vegetables, legumes, oats, and wholegrain bread, Prunes, kiwifruit, and pears may help stimulate bowel movements naturally, Avoid low-fibre, high-processed-food diets

Hydration: Aim for at least 2 L of water per day, Warm water or herbal teas in the morning can help stimulate bowel activity

Avoid: Refined white bread, white rice, and pastries as staples, Insufficient fluid intake, Prolonged periods of inactivity

Nutrition: Focus on soluble and insoluble fibre sources at every meal, Add a tablespoon of psyllium husk to water or food daily if tolerated, Kiwifruit (2 per day) has evidence for improving bowel frequency — try if available

Hydration: Increase fluid intake to 2–2.5 L per day, Prune juice (120–180 mL) in the morning may help

Avoid: Dairy in excess if it worsens constipation for you, Iron supplements unless essential — discuss with your trial site, Dehydrating drinks such as excess alcohol or caffeine

⚠ If you have not had a bowel movement in 4 or more days, or if you have bloating and abdominal discomfort, contact your trial site for guidance on suitable laxative options.

Nutrition: Maintain fluid and fibre intake but do not rely on diet alone at this severity, Your trial site should advise on appropriate laxative use

Hydration: Hydration remains important — aim for 2–2.5 L per day, Osmotic fluids (e.g., diluted juice or oral rehydration solutions) may assist

Avoid: Straining excessively — seek medical advice, Starting any laxative without checking with your trial site first

⚠ Severe constipation (score 7–10), no bowel movement for 5+ days, severe abdominal pain, bloating, or vomiting alongside constipation — contact your trial site promptly or seek medical attention.

Nutrition: Use reduced appetite as an opportunity to focus on food quality over quantity, Prioritise protein at each meal to support muscle mass: eggs, legumes, lean meat, dairy, tofu, Eat to a schedule rather than waiting for hunger cues

Hydration: Do not replace meals with fluids — aim to eat something solid at each meal time, Drink fluids between meals rather than immediately before eating

Avoid: Skipping meals entirely — even a small amount of nutritious food is better than nothing, Filling up on low-nutrient foods when appetite is limited

Nutrition: Switch to calorie-dense, nutrient-rich small portions: nut butters, avocado, full-fat yoghurt, eggs, Liquid nutrition supplements (e.g., fortified milk drinks) can help meet nutritional needs, Aim for at least 60–80 g of protein per day even in small amounts across meals

Hydration: Protein-enriched drinks or milk can contribute to both fluid and nutrient intake, Aim for 1.5–2 L of fluid per day total

Avoid: Going more than 4–5 hours without eating something, Relying only on fluids for nourishment

⚠ If your appetite is so reduced that you are consistently unable to eat meaningful amounts over several days, discuss with your trial site — unintended nutritional deficiency is a risk.

Nutrition: Nutritional support may be needed — speak with your trial site or a dietitian, Focus on the most calorie- and protein-dense foods in the smallest volumes possible, Medical nutrition supplements may be appropriate — ask your trial site

Hydration: Ensure you are maintaining fluid intake even if food intake is very low, Fortified fluids or oral nutritional supplements can help bridge the gap

Avoid: Going an entire day without consuming any nutrition, Delaying contact with your trial site if eating has become very difficult

⚠ Severe or prolonged appetite loss affecting your nutritional status — contact your trial site. This may require dose review or nutritional support.